Tak1(Phospho Thr187) Polyclonal Antibody, 50ul Supplements sequence-specific DNA binding and RNA

sequence-specific DNA binding and RNA polymerase II transcription coactivator activity

Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine

These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility

The protein is encoded by a bicistronic transcript which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5)

Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID)

Tak1(Phospho Thr187) Polyclonal Antibody, 50ul Supplements sequence-specific DNA binding and RNAThe protein encoded by this gene is a member of the serine threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP) and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL 1 this protein forms a kinase complex including TRAF6 MAP3K7P1 TAB1 and MAP3K7P2 TAB2; this complex is required for the activation of nuclear factor kappa