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which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin

The protein encoded by this gene contains two N-terminal doublecortin domains| which bind microtubules and regulate microtubule polymerization| a C-terminal serine/threonine protein kinase domain| which shows substantial homology to Ca2+/calmodulin-dependent protein kinase| and a serine/proline-rich domain in between the doublecortin and the protein kinase domains| which mediates multiple protein-protein interactions

Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene

Favors Hoogsteen base-pairing in the active site

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