SAE1 Polyclonal Antibody, 100ul Metabolic enzymes Variations in this gene have

Variations in this gene have been linked to metabolic syndrome

This gene is a putative tumor suppressor

and sequence variants of this gene are also associated with atrial fibrillation

Sumoylation inhibits the AP-1 transcriptional activity and is| itself| inhibited by Ras-activated phosphorylation on Thr-232

and may play a role in regulating the actin cytoskeleton

SAE1 Polyclonal Antibody, 100ul Metabolic enzymes Variations in this gene havePosttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO activating enzyme for the sumoylation of proteins.