Parkin Polyclonal Antibody, 20ul Cell Culture Plates The protein encoded by DOK2

The protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase

and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors

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inducing leukocyte migration and activation

This growth factor lacks the N-terminal signal sequence present in most of the FGF family members

Parkin Polyclonal Antibody, 20ul Cell Culture Plates The protein encoded by DOK2The precise function of PARK2 is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in PARK2 are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of PARK2 produces multiple transcript variants encoding distinct isoforms. Additional splice variants of PARK2 have