RUNX2 Polyclonal Antibody, 20ul[BT-AP08061] Dry Bath The endothelial PAS domain protein

The endothelial PAS domain protein 1 contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels

PAK5 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton

thus inhibiting SMAD3-mediated TGF-beta responses

Mutations in this gene result in disorders of male secondary sexual character development

Alternative splicing results in a multitude of transcript variants

RUNX2 Polyclonal Antibody, 20ul[BT-AP08061] Dry Bath The endothelial PAS domain proteinRUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA binding domain. Runt related transcription factor 2 is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions