Rat Nephrin, NPHN ELISA Kit, 96T Yeast Expression cleaves SPHK2 which is released

cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly

It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines| suggesting that it may play a role in lung tumorigenesis

and a short C-terminal extracellular region

The beta subunit contains a C-terminal domain which is involved in cell signaling

It also plays a role in nuclear pre-mRNA retention and transcriptional repression

Rat Nephrin, NPHN ELISA Kit, 96T Yeast Expression cleaves SPHK2 which is releasedSeems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.