PARP8 Polyclonal Antibody, 20ul Gloves This gene and two other

This gene and two other related trefoil family member genes are found in a cluster on chromosome 21

They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes

Defects in VCL are the cause of cardiomyopathy dilated type 1W

The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit

The encoded protein is also a candidate tumor suppressor protein| and aberrant promoter methylation of this gene may play a role in cervical cancer

PARP8 Polyclonal Antibody, 20ul Gloves This gene and two otherCatalytic activity: NAD(+) + (ADP D ribosyl)(n) acceptor = nicotinamide + (ADP D ribosyl)(n+1) acceptor.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Contaminating sequence. Potential poly A sequence.,Contains 1 PARP catalytic domain.,