ErbB-3 Polyclonal Antibody, 50ul[BT-AP03042] Culture Media Mutations in this gene underlie

Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome| Donohue syndrome and Rabson-Mendenhall syndrome

The BAG domains of BAG1

This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression

This family member is part of the MRP subfamily

This highly conserved protein family is found in both plants and mammals| and this protein is 99% identical to the mouse| rat and sheep orthologs

ErbB-3 Polyclonal Antibody, 50ul[BT-AP03042] Culture Media Mutations in this gene underlieERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation