Rb Polyclonal Antibody, 100ul[BT-AP07685] Monoclonal Antibody Preparation The BRCA2-Associated Factor 35 (BRAF35)

The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2

including breast and ovarian tumors

It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells

This magnesium-binding protein forms homodimers and is located in the cytoplasm

There are multiple pseudogenes of this gene dispersed throughout the genome

Rb Polyclonal Antibody, 100ul[BT-AP07685] Monoclonal Antibody Preparation The BRCA2-Associated Factor 35 (BRAF35)RB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.