c-Abl Rabbit Polyclonal Antibody, 100ul Pathway and Network Analysis Mutations in this gene are

Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients

tissue specificity:Appears to be expressed ubiquitously

|enzyme regulation:Strongly inhibited by TIMP-2| TIMP-3 and TIMP-4| while TIMP-1 is less efficient

and may be related to tumor metastasis

Mutations in CTSA are associated with galactosialidosis

c-Abl Rabbit Polyclonal Antibody, 100ul Pathway and Network Analysis Mutations in this gene areThis gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA binding activity that is regulated by CDC2 mediated phosphorylation,