Triapine - CAS# 143621-35-6 0264 (2007) Nat Biotech 25: 681-686

(2007) Nat Biotech 25: 681-686

twice daily) causes an inhibition of tumor growth in NCr athymic mice bearing established SW620 human colorectal cancer xenografts

a class III HDAC inhibitor

116(9):1524-7

01-10 µM) inhibits cell proliferation in a dose- and time-dependent manner

Triapine - CAS# 143621-35-6 0264 (2007) Nat Biotech 25: 681-686Triapine, also known as 3 AP and OCX 191, CAS No. 143621 35 6, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. Product information CAS Number: 143621 35 6