OICR9429 - WDR5 Antagonist. CAS# 1801787-56-3 Catalog No.:M60255-10S (Biochem Pharmacol

(Biochem Pharmacol

InChi: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57

is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM)

Cancer Discov

A novel small-molecule inhibitor of NF-kappaB signaling

OICR9429 - WDR5 Antagonist. CAS# 1801787-56-3 Catalog No.:M60255-10S (Biochem PharmacolOICR9429, CAS No. 1801787 56 3, is a potent and selective WD repeat containing protein 5 (WDR5) antagonist (Kd ~24 52 nM). It has >100 fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR 9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 M. Product information CAS Number: 1801787 56 3 Molecular Weight: 555. 59 Formula: