WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 426 A nonsteroidal glucocorticoid receptor antagonist

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WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 426 A nonsteroidal glucocorticoid receptor antagonistWP1130 (Degrasyn), CAS No. 856243 80 6, is a cell permeable, potent and selective inhibitor of the deubiquitinylating enzymes (DUBs). At 5 M it directly inhibits DUB activity of USP9x, USP5, USP14, UCH L1, and UCH37, but not UCH L3, resulting in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL 1 and p53. WP1130 suppresses Bcr Abl, JAK2 transducer (without affecting 20S proteasome) and activator of transcription

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