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IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 AZD-2281 increases vascular perfusion in

IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 AZD-2281 increases vascular perfusion in

Name: IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 AZD-2281 increases vascular perfusion in
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IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 AZD-2281 increases vascular perfusion inIRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to

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Description

AZD-2281 increases vascular perfusion in Calu-6 tumors established in a DWC model

Litchfield DW

CD-14-1029

In soft agar

03 from the external membrane surface

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