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SW-044248 - CAS# 522650-83-5 size:10mg solid 309(11):F933-42

SW-044248 - CAS# 522650-83-5 size:10mg solid 309(11):F933-42

Name: SW-044248 - CAS# 522650-83-5 size:10mg solid 309(11):F933-42
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SKU: 7592544193
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SKU: 7592544193

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SW-044248 - CAS# 522650-83-5 size:10mg solid 309(11):F933-42SW 044248, CAS No. 522650 83 5, is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The acute transcriptional response to SW044248 in sensitive HCC4017 cells correlated significantly with inhibitors of topoisomerases and SW044248 inhibited topoisomerase 1 (Top1) but not topoisomerase 2. SW044248 inhibited Top1 differently

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Description

309(11):F933-42

Formula: C23H31Cl2N3O2

Giuliano S

In COLO 205 and GEO colon cancer xenograft models

In BaF3 cell lines that stably express FLT3-ITD/N676D

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