Topotecan Hydrochloride Catalog No.:M9750-2 Effect of KAD-1229
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Topotecan Hydrochloride Catalog No.:M9750-2 Effect of KAD-1229Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I DNA covalent complexes, inhibiting religation of topoisomerase I mediated single strand DNA breaks and producing potentially lethal double strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline based alkaloid
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