AGN 194310 I-3 avian coronavirus

avian coronavirus

Apilimod inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases - through the prevention of nuclear translocation of c-Rel

A phase I study of tasisulam sodium (LY573636 sodium)

including neurodegeneration

The agent may enhance expression of the TGFβ-1 gene in a fashion analogous to that demonstrated for CsA

AGN 194310 I-3 avian coronavirusAGN 194310, also known as VTP 194310, is a pan antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR , RAR and RAR, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR , RAR and RAR, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+ grown cell lines with IC50 values of 16